In the last scene of AoS, set in present day, a character was seen driving away, & in the background was the Triskelion. Since it was destroyed in WINTER SOLDIER, the producers inserted it to show that this was a slightly tangent reality where some events from the MCU happened, like the events of DARK WORLD, where the agents were shown doing cleanup in England, & the breakup of SHIELD, but in this reality, the headquarters weren't destroyed.Here's the thing, though. Have we gotten clarification as to whether Runaways is part of this same live-action universe? Or, for that matter, Agents of S.H.I.E.L.D.? The Darkhold has been in both, and I can't remember if it looked like this book.
Not sure about RUNAWAYS though.