Well, technically, there is a reaction between the primer and the resin. The reaction being is that the primer is not bonding the way it's supposed to.
Before we get too far, here's a little primer on primer (and flat and gloss coats). Primers and flats are flat because of the way the paint is designed to dry. The paint molecules dry pointing in all diffrent directions. This causes reflecting light to scatter, giving the flat coat it's dull appearance. Gloss coats on the other hand, are designed to dry so that the molecules all line up. This refelects light back at a predictable angle and gives the paint it's glossy appearance.
The way primer works is it creates a mechanical bond with the material it's sprayed on. It forms this bond by being a "grit" coat. The grit gets into the microfisions in the resin surface. Then as you spray another coat of primer, it chemically bonds to itself. When you spray your top coat (flat or gloss), it bites into the grit of the primer because it's sitting in all the little grooves in the primer. Then supplemental layers of top coat are chemically bonding to itself. It's also why you have to spray supplemental layers in either the first 24 hours or after 7 days. Any time in between then, the original paint will be curing (degassing and releasing the carrier agent) and cause all kinds of grief. In the first 24 hours, the paint has only started to cure, but new paint will bond just fine. After 7 days, the paint has fully cured, so painting over that is like painting over the original surface (but the carrier agent in the new paint will soften the existing layer just enough to allow a chemical bond).
But now back to your question. You need to seal the resin prior to doing any painting. This is beacuse the resin is still gassing out (the weeping). If you don't get it to stop or at least seal it in, you'll always run into the same problem. So, here is a simple step-by-step;
1) Wash the resin in warm, soapy water (use a soap that has a grease cutter ingredient).
2) Wash the resin with Simple Green - this is an industrial grease cutter.
3) Wash again with warm soapy water, just to remove any Simple Green residue.
4) Wait a week and see if it's still weeping. If it's not, you're golden and you can prime and paint as usual.
5) If it is, you have uncured resin on your hands which leads us to...
6) You have to seal this resin one way or another. Now, you can use future floor wax or a thin layer of CA glue. I know CA glue will seal against weeping resin. FFW is a tossup depending on the type of resin used to make the piece. Which is why I suggested testing on a small piece.
7) After you've sealed the resin and created a physical barrier between the resin and the paint, you can go ahead and prime, then paint and finally seal with either more FFW or an automotive clear coat.
Hope that clears everything up :cool
-Fred