Personally, the problem I felt with She-Hulk (the tv show) was that the 4th wall breaking was pretty much just in one episode, and was much more of an extreme break than anything in the Deadpool movies. Deadpool mostly just makes references to our "real world," looks at the camera, which you could just explain in-universe that he's just kind of crazy, and makes weird references that no one in his world would really understand, and mugs for a non-existent camera.
The "suspension of disbelief" that we have to have when watching movies and tv was much harder to have for the She-Hulk stuff than for Deadpool. She-Hulk's 4th wall breaking also breaks the rest of the connected MCU, with the onscreen content blatantly acknowledging that none of this is real, which ruins our suspension of disbelief.
Comic books are a bit different, but even so, I never read She-Hulk or Deadpool, and I would have the same criticisms when things are taken too far. It would be better to have the She-Hulk show exist in a different universe. It's also the problem of trying to connect everything in a shared universe, so that you inevitably run into problems when films and shows don't match in tone, or when characters and the world shown in each separate film/show present things that wouldn't make sense if all were truly interconnected.
Take Daredevil. The tone of the show tends to be more of a crime-drama, a little more grounded than other fantastical MCU properties. When you try to connect the NYC in Daredevil and DD: Born Again, it doesn't really fit with the MCU as shown in The Avengers connected movies and GOTG. The gritty organized crime element and doesn't really fit the tone of the MCU. Daredevil's powers are more grounded - even though he's blind and has radar senses, his physical strength isn't really unbelievable. Putting him in The Avengers would present problems of the scale of power. I'm not saying they couldn't do it and make it look someewhat believable within the context of a big action movie, but it's harder to separate him from how he appears in his own series.
The world of Daredevil works better when it largely ignores the rest of the MCU. I mean, if there's gang members running around (or flying) in NYC that have alien-based weapons, like the Vulture was peddling in Spider-Man: Homecoming, it kind of breaks the Kingpin's crime world.
I guess it really comes down on how much you are willing to believe all these properties are connected. For me, it's a bit easier to enjoy Daredevil as being more grounded than it was to have She-Hulk literally break the 4th wall and climb into "the real world." I still enjoyed She-Hulk as a series, but the 4th wall stuff just was too far for me.