I love this series! But I think seven seasons is stretching it, a four or five season run would be good. We already have the first season that establishes the players, then next season could be Red Dragon, the third Silence of the Lambs (really gutsy, but I think Mikkelsen could match or surpass Hopkins), the fourth Hannibal, and maybe a fifth original conclusion to the character. I like the idea of knowing that Hannibal is out there somewhere at the end, just like at the end of Silence. But three seasons of original material is too much, I might get bored by then.
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Either way I think we can count on the show going on past Red Dragon, it is called Hannibal after all not Grahm, not Crawford, not CSI Maryland, but Hannibal, now we're just waiting for the bomb to go off.