So, first impressions, these are just initial impressions without thoroughly delving into the text:
This game a has numerous positives:
In the positive: It is an official Blade Runner rpg -finally, the core rulebook is nicely assembled with maps of the city inside the cover where there normally are blank areas, a timeline of history, coverage of aerial combat and spinner chases, character development that includes levels of humanity (how humane a character is rather than how human a character is -that is called "human supremacist"), detailed case files to base investigations on, the artwork is not distracting from the theme, the inclusion of the KIA device from the 1998 game, lots of background material to cover for players -probably as a cushion for their emotions.
It also has some negatives:
Some of the conventions are odd: heavy reliance on dice(nothing really new here), character roles that maybe better suited to cyberpunk rather than Blade Runner, wasted segments dealing with the comfort level of players and while simultaneously having paragraphs filled with inappropriate expletives, no references addressing animal murder(a major theme in the 1998 computer game), overly flexible time segments where a round can be 5-10 seconds, unnecessary inclusion of a card mechanic that could easily be replaced by a die roll since dice are already emphasized, limited knowledge of injuries/damage effects, no need to count ammo, nonexistent bridging of technology and history between films(while events are mentioned, the technology leaps from 2019 to 2049 without intermediate stages) there is no obvious way to play periods not expressly outlined, no mention of the Lobster Spinner and its uses, Holden is somehow still alive after all this time (2037) and a deputy chief, no mention of square gate technology and how ships travel to distant colonies, no mention of cults like Mercerism, no mood organs, vehicles can not take cover and are somehow always exposed to attack and damage, awkward writing -unexpeted changes in tone and reference, sentence fragments galore, just to name a few.
This is just preliminary though, your milage may vary.