what andy said... inserts.
If there's to be any sort of force on the screws, the resin won't hold up and the threads will strip. This includes over tightening. You won't need much to utterly destroy the thread.
If you absolutely need to thread the resin, you can either cast the hole smooth or just fill the hole on the master leaving a small indent of where the hole is, then drill & tap it after. I would go for this option as casting the hole (smooth or not) could cause the piece to lockup in the mold and result in possible damage to the mold to get the casting out.
And if you don't want to put too much strain on the material when you tap it, go with a slightly larger drill bit... Example: if your tap is a 6mm, the drill needed - normally - would be a 5mm (0.1968), use a slightly larger 5.2mm (0.2047) bit. The screw may not be as tight as with a thread made in a 5mm hole, but it's tight enough to do the job and you won't be putting as much pressure on the resin while tapping.