If it wasn't for Fallout 4's ability to play as a female character, this game would be the most female unfriendly game I've played since StarCraft 2. Let me explain.
If you play as a male PC, your wife is murdered and locked in a freezer. Upon examining your wife, you vow to find whoever did this. I cannot think of a more literal example of 'Women in Refrigerators' outside of the one comic
that spawned it. Now I know what you're thinking. "Just play as a female character and it will be your husband that gets killed. No dead female character used as motivation for the male character". Well first, dead husband is very unfortunate as well, and second? The game manages to still rely on that dreaded trope in the worst possible way. When you enter Kellogg's mind to find out what he knows about the Institute, you discover that before he was a merc, he had a wife and daughter. It's such a 'by the numbers scene' it shows him promising how he'll protect his wife and daughter and how much his wife is rooting for him. But the very next memory you experience is of him walking down a hallway with a gun and a voice heard in the background,
Voice: (To Kellogg) Just so you know, they died like dogs. And you weren't there to help them.
And a few moments later, we're treated to the murder of the player's spouse again from Kellogg's point of view, complete with his thoughts on how murdering an unarmed person who was simply protecting their child was the right thing to do. Just because the murdered spouse can be male doesn't mean Bethesda is off the hook for resorting to this disgusting trope because they take it to it's absolute worst with Kellogg's story. I know the Fallout universe is supposed to be dark, ugly and violent, but they were able to showcase that in ways that only the Fallout franchise could.
Vault 11 is a prime example of that.