Yes, the ideal ISO chip would be laser cut. And many ISO chips were screen printed on both sides, but not all of them were. Heck some of them (the non-hero chips) were unprinted colored acrylic with printer paper glued around the top, often then only with a colored dot or two printed on the paper label. I'll try to dig up some pix if anyone wants to see them.
I don't know if printing up a whole bunch of chips on a single sheet of acrylic and then laser cutting them would be optimal, or laser cutting a bunch of chips and then having them silk screened would be the better choice. I'll have to ask the person who normally does my laser cutting. Or perhaps ZK's silk screening buddy could shine some light?