It is hard to say how much any given crowd will react. Look at Matrix Online, they thought that thing would be huge, I played the Beta, and they changed some stuff with combat, and I hated it. In the end, I don't even think it lasted too long. Not like say Star Wars, or WoW, where they have a huge fanbase and can easily get the numbers to play.
All I know is, they better do it right, and not mess something up with all the various issues, mainly freezing, that 3 and NV had. Plus, they have to find a way for people to store their stuff. While the game itself has fallen far, SWG had a great way to store stuff with housing, it was near perfect. However, with it being the wasteland, we wouldn't be able to just put houses anywhere. But, that is where we can do something like the cities, or even Vault rooms. I'd have to get in on the beta to fully see if I would be interested, as I have been very picky with MMO's.