After absorbing everything I can get my hands on, I am optimistic for this game. At the very least Bethesda won't just shove it down our throats and tell us to deal with bad mechanics as-is. (Looking at you EA)
I am still sticking to my guns that this will be a map conquest style game. Where quest lines center around control and defense of a nuke and the surrounding areas.
Because the nukes directly change the in-game world, I predict that you will not be able to target anywhere on the map. I bet instead you only get to target a few select places on each of the six zones. This would be a game mechanic that allows you to strategically take out another team who has control of that area. With an end-goal of controlling the whole map, or destroying it.
The actual gameplay so far sounds a lot like Coop Borderlands.