I have been using polyurethane resin almost full time for 20 years now both for my home Business and professionally, I never wear gloves , cant stand them , and use good ventilation when pouring , I tend to pour pieces 4-7 hours a day in my Garage , I do not wear a mask or respirator, When sanding I use a table top belt sander and have a shop vac hooked up to it to collect the dust , If I am doing a lot of sanding I will wear a particulate mask just to be safe , I have never had a reaction , and the worst experience I have had is when i have gotten resin in the eye WEAR SAFETY GLASSES :lol
Of course that does not mean 20 more years from now the stuff wont kill me .
With that said , we hired a guy to do casting once in the early 90's , withing a week he was covered in hives and rashes , he looked like a burn victim, so it all depends on you and your sensitivity to the stuff !