Let me elaborate, actually..
For starters, go over to uspto.gov and look up John Moses Browning's patents (yes,
that JMB. The man has his fingerprints on just about everything that goes "bang" these days, and that's no exaggeration.).
ANYHOW.. look at the patent for the original 1892 carbine. You'll see not only is it striker-fired rather than hammer fired, it feeds from a detatchable box magazine. (I presume Winchester changed it to the traditional tube mag/hammer arrangement to appeal to their existing customer base when they bought the rights to make said boomstick.)
So there we have our guts. The bolt PULLS the round out of the top of the magazine, then lifts it up into the chamber like a regular lever gun. So far so good -- more than enough room to accomplish that in the Mal pistol. Coincedently, this setup works GREAT with rimmed "revolver-like" cartridges as we see used on Firefly a fair amount. The long reciever can even let the bolt reciprocate without slamming into your firing hand if you hold it stupid (like Mal sometimes does).
You want semi-auto? Easy.. those "screws" on the side can be gas tubes, taking gas from the barrel down to impinge on a bolt lockup. I was thinking something akin to CZ-50-something roller locking, but there's prolly a better way. The trick it that taking gas off this close to the breech isn't a terrible good idea.. having a gas tube running down closer to the muzzle (like the "loading lever" on the original concept of the prop actually.) would be much better.
So we come to cycling the action. If we use the "loading lever" gas tube, we can use those long screws as long-axis bolt "handles" -- grab the weapon with your finger tip on the front left screw, your thumb hooked in the trigger guard, and pinch -- just like old-timey 1911 pinch checks, but safer.
If we use those screws instead for gas ports, then we can use the rear sight wings as an AR-style cocking lever. Not the best choice, but it'd work. Or there might be some way of letting the "screws" do double duty, I'm not certain.
Mag release? Easy -- those "T" areas on either side of the forward reciever. Pinch in at the top, and the bottoms lever out, disengaging from grooves in the magazine. Just pinch the top of the T and out pops the mag.
And now we come to the real hassle. Getting the hammer impulse from the hammer to the cartridge primer. See, if we have a reciprocating bolt inside the reciever, then there's no way for the hammer dropping at the back of the reciever to be able to reach the rear of the bolt -- there's that big empty space between the two where the bolt needs to reciprocate to eject empties and load the next round.
We can't put the hammer inside the receiver in the position hammers normally go in with a mag-fed semi auto, because the "pull the cartridge out backwards" monkey motion gets in the way. We don't want to use a "strip straight off the top" mag, 'cause that leaves us with about 2" of usable barrel in a big ol' hogleg. Also not good. Alternately, we could have a bolt run the entire length of the receiver, and work just like the lever guns do.. the downside there is that you have the bolt running punching about 2" out the back of the gun with every shot. It's the simplest most rugged solution I can think of, but with that grip angle you're begging to chew your hand up with the slightest inattention.
Bother. Where's Matsuo when you need him?