Here's the thing. I've heard Bridesmaids is really good and funny. And that's great. The Heat looked kinda lame, but whatever. But simply mapping that dynamic on top of the Ghostbusters IP just strikes me as, well, lazy. If it's funny, it wouldn't be because of the ghost-busting activities of these people. It'd just be these actresses doing their schtick in a Ghostbusters setting.
Ultimately, this is my problem with reboots and remakes. To the extent these films succeed at all, it is in spite of the IP to which they're attached. If anything, the IP acts as a millstone round the neck of the whole creative process. You have to write everything to the IP, instead of just allowing the story to grow organically. You have to make the material fresh, but still familiar, which is a damn-near-impossible task. It either feels like lukewarm microwaved leftovers, or it feels so different that there's really no reason to use the IP at all in the first place, except for obvious manipulative marketing.
What made the first Ghostbusters work is the same thing that probably made Bridesmaids work, and The Hangover 1, and other similar films: the story and the humor were organic to each other.
With this, I just see the following goal: "Write a Ghostbusters movie that isn't the same Ghostbusters movie we've seen, but follows the same plot points without reusing the same jokes and which isn't so different that it's unrecognizable but isn't so familiar that it's a shot-for-shot remake."
And the solution?
"They're CHICKS!!!"