Bethesda really wanted to get away from the original games and it's why they've lost a lot of fans. The old X-com franchise is getting the same treatment, from turn based to FPS and it's not going over well. I wish bethesda would just let Interplay make the games and them handle the releasing. Actually I'm not even sure Interplay really exists anymore. I know Tim Cain who created Fallout has his own company now.
I would really love a prequel to Fallout where you survive the war and are one of the lucky few not in a vault to survive, you could have your storyline change depending on how much radiation you get thereby staying human (or with a wink to fallout 2 grow extra parts) or become a ghoul. If bethesda hadn't taken over the franchise we'd have Fallout online and fallout 3 (i forgot Interplay's name for it) but instead we have Bethesda using the design docs for bits and pieces of that game mixed with their own stuff. The Legion and Caesar were meant to be in the Interplay fallout 3 as was a space station, old prewar bases and bunkers, ghouls who can reproduce and stuff like that.
Given the fact that it's the midwest even if it's an alternate timeline to ours there should be tons of bunkers and stuff like that which could be used for quests. Heck even some silly stuff like in the originals would be nice, I miss that twisted black humor you'd get now and then and random encounters that were cool such as Dr Who, star trek, and Monty Python jokes. I'm betting that the guys from the original series working on New Vegas had a ton more they wanted to do that they weren't allowed. I mean Fallout 1 and 2 were their babies so we know they know how to make games. Bethesda seems to be a very...strict company when it comes to stuff and New Vegas feels like they forced everyone to finish it ahead of time just by the sheer number of glitches in the game.