"The Cybermen" from Dr Who, originally from Mondas, a twin planet to Earth, they were a dying race, so Mondasians decided to "upgrade" their entire bodies, like "transhumanism", becoming cybernetically augmented humanoids, without the need of emotions.
"Major Motoko Kusanagi" from Ghost In The Shell. "Major" was human, when she died her brain and spinal cord were put inside a cybernetic body.
There is the "alternate" version, her spirit/soul is in the machine, hence the title. A lot of fans hated the Hollywood movie because of "whitewashing", so for the purpose of this post, I've added the anime version too.