You're going to find that print settings are a very individual thing. What's right for one machine may not be good for another, even of the same make and model, due to variances in the quality of the machine's parts. Printing temperatures and print speeds are going to vary by material, and by individual brand of material. And frequently by different colors from the same manufacturer. Or different batches of the same color. And... or... well, you see where I'm going with this.
There are some things you can start with though. Cura should have a pre-made starter profile for the CR-10 series printers under "Other" when you set up or add a printer. If you plan on printing with PLA, try a baseline of 200 degrees at the hot end, 50 degrees on the bed, and maybe 45 mm/sec print speed. That's usually a fairly safe set of parameters for most PLA, even if it's not the perfect combination.
Things like infill, supports, number of shells/walls and top/bottom layers.... that stuff can vary on every print, and it's just something you have to play with and gain some experience in. Unfortunately there are no magic numbers you can plug in to make sure it Just Works™ every time... you kind of have to accept that you're liable to have some spectacular print failures at first until you get a little knowledge under your belt. And after that too, when you forget to change one important setting, or the power goes out, or the cat jumps on the machine, or....