This is a replica of the Leonardo Da Vinci painting of Drew Barrymore in Ever After: A Cinderella Story. It was made in-house at 20th Century Fox and photo printed on real canvas (not sure technically how but I think they used a large format negative of the original prop) and was given as a gift to only a handful of VIPs from the film's cast and crew. It has never, to my knowledge, been available to anyone else in any other way. Well, except for the few I was able to end up with of course. : )
The portrait is large, measures 10x14 inches, with the surrounding canvas going out a few inches more than that. Really looks like Drew Barrymore as painted by Da Vinci (even down to a replica of his signature). It was based on one of his real paintings.
Here's a pic of the one I have and a screenshot of the one in the movie (I think the one in the movie was actually painted on wood if I remember right).