For me it would be the original 2 Deus Ex games (have a HR 2 and then tie it in with the original more to give more closure to the open ending of HR1).
Final Fantasy 7. Square is danged near bankrupt and refuses to do this game even though they have all the character models from the other FF7 games and movie. This would make them a fortune.
I want a port of the Iphone Transformers G1 game.
I'd love someone to do collections of NES/SNES and sega games updated for new systems. New graphics and maybe storyline items only but not changing how the game is played (no turning it into a FPS or something).
I'd love the shadowrun games to be remade (again no making them an FPS) and have the Japanese only one brought over.
Metal gear 1 and metal gear 2 Solid snake (no snake's revenge crap please): the creator said he'd give the okay but doesn't have time to do it himself. I think making them to play like the MGS games would work really well and it would get tons of new gamers who are fans of the MGS series.